导师信息#兰州大学基础医学院导师介绍#李文广

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姓 名: 李文广Name:Li Wenguang职 务：教授Duty: ProfessorE-mail：wenguangli2003@yahoo.com.cn
一、科研方向
抗肿瘤药理学。新药临床前药理学。Research Interests：Antitumor Pharmacology。Preclinical Pharmacology of New Drugs。二、荣誉称号及奖励：
2002年获第九届甘肃省青年教师成材奖。《葡萄籽中原花青素对阿霉素增效减毒作用及机理研究》获2006年甘肃省高校科技进步一等奖（2/8）。 honors and awards：2002 obtained The ninth Young Teachers Chengcai Award in Gansu Province。2006 Mechanisms of Proanthocyanidin from Grape Seeds in both Potentiating Anti-tumor Activity and Reducing Toxicity of Doxorubicin obtained the second prize of Gansu Provincial Natural Science. (second author)。
三、个人简历
教育背景：1983年9月至1988年7月 在原兰州医学院临床医学系攻读本科1988年9月至1991年7月 在原兰州医学院药理学攻读硕士2003年9月至2006年6月 在兰大生命科学学院攻读博士工作经历：1991年7月至1994年7月 兰州医学院药理学教研室 助教1994年7月至1998年7月 兰州医学院药理学教研室 讲师1998年7月至2003年12月 兰州医学院药理学教研室 副教授2003年12月至2004年11月 兰州医学院药理学教研室 教授2004年11月至今 兰州大学药学院药理学教研室 教授Resume：Education：Sept. 2003至 June 2006 Ph.D. in the Life Science School of Lanzhou University, Lanzhou 730000, Gansu, P.R.ChinaSept. 1988至June 1991 M.S. in Pharmacology, the Department of Pharmacology of Lanzhou Medical College, Lanzhou 730000, Gansu, P.R.ChinaSept. 1983至July 1988 B.S. in Clinical Medicine, the Department of Clinical Medicine of Lanzhou Medical College, Lanzhou 730000, Gansu, P.R.ChinaWorking Experiences：Nov. 2004至NowProfessor, Institute of Pharmacology，School of Basic Medicine Science, Lanzhou University, Lanzhou 730000, Gansu, P.R.ChinaDec. 2003至 Nov. 2004 Professor, Department of Pharmacology，Lanzhou Medical College, Lanzhou 730000, Gansu, P.R.ChinaJuly. 1998至 Dec. 2003 Associate Professor, Department of Pharmacology, Lanzhou Medical College, Lanzhou 730000, Gansu, P.R.ChinaJuly. 1994至July. 1998 Lecturer, Department of Pharmacology, Lanzhou Medical College, Lanzhou 730000, Gansu, P.R.ChinaJuly 1991至July. 1994 Assistant，Department of Pharmacology, Lanzhou Medical College, Lanzhou 730000, Gansu, P.R.China
四、发表论文（按年度）
LI Wenguang, ZHANG XiaoYu, WU YongJie and TIAN Xuan. Anti-inflammatory effect and mechanism of proanthocyanidins from grape seeds. Acta Pharmacol. Sin. 2001; 22(12): 1117-1120. (SCI) 。LI Wenguang, ZHANG XiaoYu, WU YongJie and TIAN Xuan. Antioxidative activity of spin labelled derivatives of podophyllilic acid hydrazide. Acta Pharmacol. Sin. 2002; 23(8): 727?732. (SCI)WenGuang LI, XiaoYu ZHANG, YongJie WU, MingTang GAO and Rongliang ZHENG.. The relationship between structure and antioxidative activity of piperidine nitroxides. J. Pharm. Pharmacol. 2006; 58(7): 941?949. (SCI)Tuanming YANG, ShiFang GUO, Changrui CHENG, XiaoYu ZHANG and Wenguang LI. Anti-osteosarcoma effects and mechanisms of 4-O-amino-phenol-4′-demethylepipodophyllotoxin ether. J. Pharm. Pharmacol. 2008；60(2): 179-188. (SCI)WU Yong-jie, LI Wen-guang, ZHANG Zhen-ming and TIAN Xuan. Antioxidative activity of 4-oxy and 4-hydroxy nitroxides in tissues and erythrocytes from rats. cta Pharmacologica Sinica. 1997; 18(6):510-514XiaoYu ZHANG, WenGuang LI, YongJie WU, TianZhen ZHENG, Wei LI, SongYi QU and NaiFa LIU. Proanthocyanidin from grape seeds potentiates anti-tumor activity of doxorubicin via immunomodulatory mechanism. Int. Immunopharmacol. 2005; 5(7-8): 1247?1257. (SCI)XiaoYu ZHANG, WenGuang LI, YongJie WU, DeCheng BAI, and NaiFa LIU. Proanthocyanidin from grape seeds enhances doxorubicin-induced anti-tumor effect and reverses drug resistance in doxorubicin-resistant K562/DOX cells. Can. J. Physiol. Pharmacol. 2005; 83(3): 309?318. (SCI)XiaoYu ZHANG, WenGuang LI, YongJie WU and MingTang GAO. Amelioration of doxorubicin-induced myocardial oxidative stress and immunosuppression by grape seed proanthocyanidins in tumor-bearing mice. J. Pharmacy Pharmacol. 2005: 57(8): 1043?1052. (SCI)XiaoYu ZHANG, WenGuang LI, YongJie WU and Xuan TIAN. Antioxidative and antitumor activity of spin labeled derivatives of 4-β-amino-4'-demethylepipodophyllotoxin and their structure-activity relationship. Pharmazie. 2007; 62(6): 432?438. (SCI)TIAN Xuan, ZHANG Fu-min and LI Wen-guang. Antitumor and antioxidant activity of spin labeled derivatives of podophyllotoxin (GP-1) and congener. Life Sciences. 2002; 70:2433-2443WANG Jun-zhi, BAI De-cheng, RAO Chun-ming, LI Wen-guang, GAO Ming-tang, WANG Xiao-qi and WU Yong-jie. Effects of 2.5s mouse nerve growth factor on regeneration of injured sciatic nerves in mice and rats. Acta Pharmacologica Sinica. 1997; 18(6):501-504ZHANG Yi, WANG Jun-zhi, WU Yong-jie and LI Wen-guang. Anti-inflammatory effect of recombinant human superoxide dismutase in rats and mice and its mechanism. Acta Pharmacologica Sinica. 2002; 23(5):439-444XUE Xiao-chang, WU Yong-jie, GAO Ming-tang, LI Wen-guang, ZHAO Ning, WANG Zen-glu, BAO Chun-jie, YAN Zhen and ZHANG Ying-qi. Protective effects of pentadecapeptide BPC 157 on gastric ulcer in rats. World J. Gastroenterol. 2004; 10(7):1032-1036Xiaoyu ZHANG, Decheng BAI, Yongjie WU, Wenguang LI and Naifa LIU. Proanthocyanidin from grape seeds enhances anti-tumor effect of doxorubicin both in vitro and in vivo. Pharmazie. 2005; 60(7): 533?538. (SCI)WANG Jun-zhi, WU Yong-jie, RAO Chun-ming, GAO Ming-tang and LI Wen-guang. Effect of recombinant human basic fibroblast growth factor on stomach ulcers in rats and mice. Acta Pharmacologica Sinica. 1999; 20(8):763-768ZHANG XiaoYu, LI WenGuang, ZHENG TianZhen and LI　Wei. Effects of proanthocyanidins on contractile activity of aortic smooth muscle and platelet aggregation in experimental animals. Chin J Appl Physiol. 2005; 21(4): 383-386. (CSCD)ZHANG XiaoYu, LI WenGuang, GAO MingTang and TIAN Xuan. Protectective effect on injured myocardial cells of proanthocyanidins in vitro. Pharmacol Clin Chin Materia Med. 2001; 17(6): 14-16.(CSCD)ZHANG XiaoYu, GAO MingTang, LI WenGuang, TIAN Xuan and ZHU JuHua. The anti-lipoperoxidative effect of grape seed extract in vitro. Advanced in Free Badical Life Sciences. 1999; 7: 116-120.ZHANG XiaoYu, ZHANG YongPing and LI WenGuang. Anti-tumor activity of lanthanum nitrate Complexes with bis(2-pyridyl-N-Oxide)disulphide in vitro. J. Lanzhou University ( Natural Sci). 2004; 40Supp: 34?36. .(CSCD)ZHANG XiaoYu, LI WenGuang, WU YongJie and GAO MingTang. CHL chromosome aberration test of proanthocyanidinsfrom grape seeds. J Lanzhou University ( Natural Sci). 2002; 38(6) Supp: 15-17. .(CSCD)LI WenGuang, ZHANG XiaoYu and WU YongJie. Effect of podophyllic acid hydrozide piperidingyloxy and its derivatives on MDA formation. Chin Pharmacol Bull. 1997; 13(5): 422-424. .(CSCD)
五、学术团队
在校： 吴勇杰 高明堂 李文广 覃 红 张 坚 崔明霞 路 莉 张宝来 王 莉