导师信息#宁夏大学生命科学学院导师#王玉炯

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教授：王玉炯
王玉炯，宁夏大学教授、博士生导师，上海交通大学兼职教授、博士生导师。宁夏大学党委常委、生命科学学院院长、西部特色生物资源保护与利用教育部重点实验室主任。国家级教学名师、国务院政府特殊津贴获得者、“基础生物学”国家级教学团队带头人、教育部“创新团队发展计划”培育团队带头人、中央直接联系的高级专家。先后荣获全国模范教师、全国师德先进个人、国家“百千万人才工程”学术与技术带头人、教育部“跨世纪优秀人才”、“宝钢优秀教师特等奖”、自治区“塞上英才”、自治区“有突出贡献专业技术创新人才奖”、“100位为宁夏建设作出突出贡献英雄模范人物”、宁夏“十大杰出青年”、自治区先进工作者等奖励或荣誉称号。兼任教育部生物技术、生物工程类专业教学指导委员会委员，宁夏回族自治区人民政府学位委员会委员，宁夏高等学校本科理工科类学科专业教学指导委员会主任委员，中国微生物学会理事，宁夏生物学会理事长、宁夏大学学术委员会副主任委员。《Vaccine》、《MolecularandCellularBiochemistry》、《BritishJournalofPharmaceuticalResearch》、《Molecules》等杂志长期审稿人，《高校生物学教学研究（电子版）》副主编、《宁夏大学学报》（自然版）常务编委，《JournalofBiochemistryandMolecularBiologyResearch》、《生命世界》、《生物学杂志》编委。长期从事微生物学、分子生物学等学科的教学与科研工作。先后主持完成国家“863”计划项目、国家“973”计划项目（含前期研究专项）、国家自然科学基金项目、国家科技攻关和科技支撑计划项目等国家级项目17项，教育部重点（重大）项目4项，自治区科技攻关计划项目8项。获国家一类新药证书1项，获省部级科技进步一等奖2项、二等奖5项，申请国家发明专利4项，获国家级教学成果奖二等奖1项、自治区教学成果奖特等奖1项（以上奖项均为第一完成人）。在《Vaccine》、《PlosOne》、《MolecularImmunology》、《Mol.andCell.Bio.》等国内外期刊发表论文100余篇。曾多次应邀赴美国、日本、比利时等国家进行学术交流。近期发表的主要论文:1.ChunyanMa.,YongLi.,JinZeng,XiaolingWu,XiaomingLiu*andYujiongWang*.MycobacteriumbovisBCGTriggeredMyD88InducesmiR-124FeedbackNegativelyRegulatesImmuneResponseinAlveolarEpithelialCells,PLOSONE,April2014,Volume9,Issue42.ChunyanMa,YongLi,MinLi,GuangcunDeng,XiaolingWu,WilliamC.S.Cho,XiaomingLiu∗andYujiongWang∗.MicroRNA-124negativelyregulatesTLRsignalinginalveolarmacrophagesinresponsetomycobacterialinfection,MolecularImmunology,62(2014)150–1583.WuLi,GuangcunDeng,MinLi,LipingZhao,XiaomingLiuandYujiongWang∗.ArecombinantadenovirusexpressingCFP10,ESAT6,Ag85AandAg85BofMycobacteriumtuberculosiselicitsstrongantigen-specificimmuneresponsesinmice,MolecularImmunology,62(2014)86–954.XiaolingWu,GuangcunDeng,JinZeng,ChunyanMa,XiaomingLiu*andYujiongWang*.ACaspase-DependentPathwayIsInvolvedinWnt/β-CateninSignalingPromotedApoptosisinBacillusCalmette-GuerinInfectedRAW264.7Macrophages,Int.J.Mol.Sci.2014,15,5045-50625.Peng-xinXu,Shao-weiWang,Xiao-linYu,Ya-jingSu,Yu-jiongWang∗,Rui-tianLiu∗.RutinimprovesspatialmemoryinAlzheimer’sdiseasetransgenicmicebyreducingA_oligomerlevelandattenuatingoxidativestressandneuroinflammation,BehaviouralBrainResearch,264(2014)173–1806.BoYang,XiaomingLiu,MinLi,YiYangandYujiongWang∗.GeneticAssociationofrs1800780(A→G)PolymorphismoftheeNOSGenewithSusceptibilitytoEssentialHypertensioninaChineseHanPopulation,BiochemGenet(2014)52:71–78DOI10.1007/s10528-013-9628-37.J.X.Dai,X.M.LiuandY.J.Wang∗,DiversityofendophyticbacteriainCaraganamicrophyllagrowninthedesertgrasslandoftheNingxiaHuiAutonomousRegionofChina,GeneticsandMolecularResearch13(2):2349-2358(2014)8.Y.Yang,J.R.Xu,X.M.Liu,J.Zhou,M.LiandY.J.Wang∗,Polymorphismsof+2836G>AintheapoEgenearestronglyassociatedwiththesusceptibilitytoessentialhypertensionintheChineseHuipopulation,GeneticsandMolecularResearch13(1):1212-1219(2014)9.YujiongWang,YongLi,XiaomingLiu,*andWilliamCSCho,*GeneticandEpigeneticStudiesforDeterminingMolecularTargetsofNaturalProductAnticancerAgents,CurrentCancerDrugTargets,2013,13,506-51810.YujiongWang,GuangcunDeng,XiaomingLiu*andWilliamC.Cho*.MonoclonalAntibodiesinLungCancer,ExpertOpinioninBiologicalTherapy,(2013)13(2):209-22611.GuangcunDeng,JinZeng,MinjieJian,WenmiaoLiu,ZhongZhang,XiaomingLiuandYujiongWang*.NanoparticulatedHeat-stable(STa)andHeat-labileBsubunit(LTB)recombinanttoxinimprovesvaccineprotectionagainstEnterotoxigenicEscherichiacolichallengeinmouse,JournalBioscienceandBioengineering,JBiosciBioeng,2013.115(2):147-15312.B.Yang,J.R.Xu,X.M.Liu,Y.Yang,M.LiandY.J.Wang∗.Polymorphismsofrs1799983(G>T)andrs1800780(A>G)oftheeNOSgeneassociatedwithsusceptibilitytoessentialhypertensionintheChineseHuiethnicpopulation,GeneticsandMolecularResearch12(3):3821-3829(2013)13.MiaoGao,HuiYang,JiZhao,JunLiu,Yu-jiongWang*,Jian-guangSun*.Paenibacillusbrassicaesp.nov.,isolatedfromcabbagerhizosphereinBeijing,China,AntonievanLeeuwenhoekDOI10.1007/s10482-012-9849-114.XuezhangZhou,YuyanZhang,YongLi,XiujingHao,XiaomingLiu*,andYujiongWang*,AzithromycinSynergisticallyEnhancesAnti-ProliferativeActivityofVincristineinCervicalandGastricCancerCells.Cancers.2012.4,1318-133215.WuLi,GuangcunDeng,XiaomingLiuandYujiongWang*.RolesofMucosalimmunityinMycobacteriainfection,TuberculosisResearchandTreatment,2012.1-12.ArticleID79139216.JinxiaDai,XiaomingLiuandYujiongWang*.GeneticdiversityandPhylogenyofRhizobiaisolatedfromCaraganamicrophyliagrownindesertsoilofNingxiainChina,GeneticandMolecularResearch,2012.11(3):2683-2693.17.Shao-weiWang,Yu-JiongWang*,Ya-jingSua,Wei-weiZhou,Shi-gaoYang,RanZhang,MinZhao,Ya-NanLi,Zi-pingZhang,Da-weiZhan,Rui-tianLiu.Rutininhibitsb-amyloidaggregationandcytotoxicity,attenuatesoxidativestress,anddecreasestheproductionofnitricoxideandproinflammatorycytokines.NeuroToxicology,2012.33(3):p.482-90.18.Xue,D.,M.Zhao,Y.J.Wang*,Rui-tianLiu.etal.AmultifunctionalpeptiderescuesmemorydeficitsinAlzheimer'sdiseasetransgenicmicebyinhibitingAbeta42-inducedcytotoxicityandincreasingmicroglialphagocytosis.NeurobiolDis,2012.46:701-919.XuezhangZhou,FangJibbndYujiongWang*.TotalAlkaloidsofSophorebblopecuroides-induceddown-regulationofAcrAB-ToLCeffluxpumpreversessusceptibilitytoCiprofloxacininclinicalmultidrugresistantEscherichiacoliisolates.PhytotherapyResearch,2012.doi:10.1002/ptr.4623.20.YongLi,YujiongWang*andXiaomingLiu*,TheroleofairwayepithelialcellsinresponsetoMycobacteriainfection,ClinicalandDevelopmentalImmunology,2012.12:DOI:10.1155/2012/79139221.JinruiXu,YiYang,XiaomingLiu,JingyinSunandYujiongWang*.Geneticvariationandsignificantassociationofpolymorphismrs7700944G>AofTIM-4genewithRheumatoidArthritisintheChineseHanandHuiPopulations.InternationalJournalofImmunogenetics,2012.39(5):409-413.22.XuezhangZhou,FangJia,XiaomingLiu,CongYangandYujiongWang*.TotalAlkaloidsfromKudouziincreasesusceptibilityofExtended-Spectrumb–Lactamases-producingEscherichiacoliisolatestoCefotaximeandCeftazidime.ChineseJournalofIntegrativeMedicine,2012,18(2):DOI:10.1007/S11655-01100899-423.JinruiXu,YiYang,XiaomingLiu,JingyinSunandYujiongWang*.AssociationofthePolymorphismsofTIM-1GenewithRheumatoidArthritisintheChineseHuiMinorityEthnicPopulation.GeneticandMolecularResearch,2012,11(1):61-69.24.XuezhangZhou,LiZhao,XiaomingLiu,XueqiangLi,FangJiaYujiongWang*.Antimycobacterialandsynergisticeffectsof18-β-glycyrrhetinicacidorglycyrrhetinicacid-30-piperazineincombinationwithisoniazid,rifampicinorstreptomycinagainstMycobacteriumbovis.PhytotherapyResearch,2012,26(2):253-258.25.JinruiXu,YiYang,XiaomingLiu,andYujiongWang*.The-1541C>Tand+4259G>TofTIM-3PolymorphismsareassociatedwithRheumatoidArthritisintheChineseHuiPopulation.InternationalJournalofImmunogenetics,2011,38(6):513-518.26.Xue-tingDu,LiWang,Yu-jiongWang*,MariaAndreasen,Da-weiZhan,YingFeng,MinLi,MinZhao,DanielOtzen,DiXue,YangYangandRui-tianLiu,A_1-16CanAggregateandInducetheProductionofReactiveOxygenSpecies,NitricOxide,andInflammatoryCytokines，JournalofAlzheimer’sDisease，2011.27(2):p.401-13.27.XuezhangZhou,FangJia,XiaomingLiu,JinhuiYangandYujiongWang*.InVitrosynergisticinteractionof5-O-methylglovanonandampicillinagainstampicillinresistantStaphylococcusaureusandStaphylococcusepidermidisisolates.ArchivesofPharmacalResearch,2011,34(10):1751-1757.28.YongLi,JingWang,HaiyanHe,LingjieMa,JinZeng,XiaomingLiu,JohnF.EngelhardtandYujiongWang*.ImmunohistochemicaldemonstrationofairwayepithelialcellmarkersofGuineaPig.TissueandCell,2011,43(5):283-290.DOI:10.1016/j.tice.2011.05.00329.JinZeng,GuangcunDeng,JingWang,JingZhou,XiaomingLiu,QingXieandYujiongWang*.PotentialprotectiveimmunogenicityofrecombinantClostridiumperfringensa-β2-β1fusiontoxininmice,sowsandcows.Vaccine,2011,29(33):5459-5466.DOI:10.1016/j.30.ZipingZhang,XiaomingLiu,XuZhang,JunhongLiu,YanfangHao,XueyunYang,andYujiongWang*.ComparativeevaluationoftheantioxidanteffectsofthenaturalvitaminCanalog2-O-β-D-glucopyranosyl-L-ascorbicacidisolatedfromGojiberryfruit.ArchivesofPharmacalResearch,2011,34(5):801-810,DOI:10.1007/s12272-011-0514-4.31.MinLi,ChunjiMa,XiaomingLiu,DongZhao,QingchunXuandYujiongWang*.MolecularcloningofHSP70inMycoplasmaovipeneumoniaeandcomparisonwiththatofothermycoplasmas.GeneticandMolecularResearch,2011,10(2):834-848,DOI10.4238/vol10-2gmr1193.32.XuezhangZhou，ZhenweiSong，XiaomingLi，FangJia，YujiongWang*.ProductionofRecombinantPorcineInterferonalphaUsingPHB–Intein-MediatedProteinPurificationStrategy.ApplBiochemBiotechnol.(2011)163:981–993.33.ZipingZhang,XiaomingLiu,TaoWu,JunhongLiu,XuZhang,XueyunYang,MichaelJ.Goodheart,JohnF.Engelhardt,YujiongWang*.SelectivesuppressionofcervicalcancerHelacellsby2-O-β-D-glucopyranosyl-L-ascorbicacidisolatedfromthefruitofLyciumbarbarumL.CellBiolToxicol.(2011)27:107-12134.GuangxianXu,HaoJia,YongLi,XiaomingLiu,MinLi,YujiongWang*.HemolyticphospholipaseRv0183ofMycobacteriumtuberculosisinducesinflammatoryresponseandapoptosisinalveolarmacrophageRAW264.7cells.Can.J.Microbiol.2010,56:916–924.35.GuangxianXu,YanZhang,HaoJia,JuanLi,XiaomingLiu,JohnF.Engelhardt,YujiongWang*.CloningandidentificationofmicroRNAsinbovinealveolarmacrophages.MolCellBiochem.2009,332:9-16.36.WangXP,ZhangJH,WangYJ*,FengY,ZhangX,SunXX,LiJL,DuXT,LambertMP,YangSG,ZhaoM,KleinWL,LiuRT.Conformation-dependentsingle-chainvariablefragmentantibodiesspecificallyrecognizebeta-amyloidoligomers,FEBSLetters,2009,583:579-584.37.YingFeng,Xiao-pingWanga,Yu-jiongWang*,Xue-tingDua,Xiao-xiaSun,MinZhao,LeiHuang,Rui-tianLiu,Resveratrolinhibitsbeta-amyloidoligomericcytotoxicitybutdoesnotpreventoligomerformation.NeuroToxicology.2009,30:986-995.注：“*”为通讯作者或并列第一作者