导师信息#中国科学技术大学化学专业研究生导师介绍#张智军

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张智军单位：中国科学院苏州纳米技术与纳米仿生研究所地址：江苏省苏州工业园区若水路398号邮编：215123电话：0512-62872556个人主页：http://biomed.sinano.ac.cn/ketizu/index.php?id=32
个人简历 Personalresume张智军，男，1963年生，中科院苏州纳米所研究员、博士生导师。1984年和1987年在中国西北大学分获学士和硕士学位。1998年在日本关西学院大学获理学博士。此后曾在北京大学、日本名古屋大学、加拿大国家研究院和McGill大学从事纳米材料的合成及应用研究。2007年底回国加入苏州纳米所，从事新型纳米载药系统和纳米诊疗一体化平台的构建以及纳米支架材料用于调控干细胞功能的研究。迄今为止在包括NatureMaterials，NanoLetters，AdvancedMaterials及Biomaterials等国际学术刊物发表论文70余篇，获美国专利1项、中国专利6项。2010年以来发表的40余篇论文中，8篇入选Top10mostread/cited、亮点或封面文章；共引用2300余次，其中单篇引用超600次的1篇，超100次的7篇。受邀在国际著名学术刊物撰写综述3篇、纳米医学专著章节2篇。获2015年度教育部自然科学奖二等奖（排名第2）。已培养3名博士后，6名博士，5名硕士。课题组研究生曾获中国科学院院长优秀奖（2011）、中国科学院朱李月华优秀博士生奖（2015）、中国科学院南京分院伍宜孙奖学金（2011,2013）、研究生国家奖学金（2012）以及全国博士生学术年会优秀论文奖(2012)等。
主要论文31.Ma,Y.F.;Huang,J.;Song,S.J.;Chen,H.B.*;Zhang,Z.J.*Cancer-TargetedNanotheranostics:RecentAdvancesandPerspectives(Review),Small,2016,DOI:10.1002/smll.201600635.30.Ma,Y.F.;Wang,H.M.,Yan,D.;Wei,Y.Q.;Cao,Y.H.;Yi,P.W.;Zhang,H.L.;Deng,Z.W.;Dai,J.W.;Liu,X.T.;Luo,J.X.;Zhang,Z.J.;*Sun,S.Q.;*Guo,H.C.*MagneticResonanceImagingRevealedSplenicTargetingofCanineParvovirusCapsidProteinVP2,Sci.Rep.2016,6,23392;DOI:10.1038/srep23392.29.Tu,X.L.;Wang,L.N.;Cao,Y.H.;Ma,Y.F.;Shen,H.;Zhang,M.X;Zhang,Z.J.*Efficientcancerablationbycombinedphotothermalandenhancedchemo-therapybasedoncarbonnanoparticles/doxorubicin@SiO2nanocomposites,Carbon,2016,97,35-44.28.Shen,H.;Ma,Y.F.;Luo,Y.;Liu,X.Y.;Zhang,Z.J.*;Dai,J.W.*Directedosteogenicdifferentiationofmesenchymalstemcellinthree-dimensionalbiodegradablemethylcellulose-basedhydrogelscaffold,ColloidsandSurfacesB:Biointerfaces,2015,135,332-338.27.Huang,J.;Guo,M.;Ke,H.T.;Zong,C.;Ren,B.*;Liu,G.;Shen,H.;Ma,Y.F.;Wang,X.Y.;Zhang,H.L.;Deng,Z.W.;Chen,H.B.*;Zhang,Z.J.*Rationaldesignandsynthesisofmagneticgoldnanoflowersforefficientcancertheranostics,Adv.Mater.2015,27,5049-5056.26.Luo,Y.;Shen,H.;Fang,Y.X.;Cao,Y.H.;Huang,J.;Dai,J.W.*;Shi,X.Y.*;Zhang,Z.J.*Enhancedproliferationandosteogenicdifferentiationofmesenchymalstemcellsonelectrospungrapheneoxide-incorporatedpoly(lactic-co-glycolicacid)nanofibrousmats,ACSAppl.Mater.Interfaces,2015,7,6331–6339.25.Zhang,M.X.;Cao,Y.H.;Wang,L.N.;Ma,Y.F.;Tu,X.L.;Zhang,Z.J*,ManganesedopedironoxidetheranosticnanoparticlesforcombinedT1magneticresonanceimagingandphotothermaltherapy,ACSAppl.Mater.Interfaces,2015,7,4650-4658.24.Guo,M.;Huang,J.;Shen,H.:Ma,Y.F.;Zhang,M.X.;Zhu,A.;Li,Y.L.;He,H.;Wang,Y.Y.;Tian,X.;Ge,C.C.;Zhang,Z.J.;*Chen,H.B.*Near-infraredfluorescentcyanine-graftedgrapheneoxidewithenhancedintrinsicphotothermalperformanceforinvivotumoreradication,Adv.Funct.Mater.2015,25,59–67.23.Cao,Y.H.;Ma,Y.F.;Wang,H.M.;Zhang,M.X.;Tu,X.L.;Shen,H.;Dai,J.W.;Guo,H.C.*;Zhang,Z.J.*Ultra-smallgrapheneoxide-supportedgoldnanoparticlesasadjuvantimproveshumoralandcellularimmunityinmouse,Adv.Funct.Mater.2014,24,6963–6971.22.Ma,Y.F.;Shen,H,;Tu,X.L.;Zhang,Z.J.*Accessinginvivotoxicityofgraphenematerials:currentmethodsandfutureoutlook(Review),Nanomedicine,2014,9,1565-1580.21.Chong,Y.;Ma,Y.F.;Shen,H.;Zhou,X.;Xu,J.Y.;Fan,S.J.*;Zhang,Z.J.*Invitroandinvivotoxicityofgraphenequantumdots,Biomaterials,2014,35,5041-5048.20.Tu,X.L.;Ma,Y.F.;Cao,Y.H.;Zhang,M.X.;Zhang,Z.J.*PEGylatedcarbonnanoparticlesforefficientinvitrophotothermalcancertherapy,J.Mater.Chem.B,2014,2,2184-2192.19.Zhang,M.X.;Cao,Y.H.;Chong,Y.;Ma,Y.F.;Zhang,H.L.;Deng,Z.W.;Hu,C.H.;Zhang,Z.J.*GrapheneOxideBasedTheranosticPlatformforT1-WeightedMagneticResonanceImagingandDrugDelivery,ACSAppl.Mater.Interfaces,2013,5,13325-13332.18.Shen,H.;Liu,M.;Chong,Y.;Huang,J.;Zhang,Z.J.*Synthesis,proteindelivery,andinvitroandinvivotoxicityofabiodegradablepoly(aminoester),Toxicol.Res.2013,2,379-387.17.Cao,Y.H.;Chong,Y.;Shen,H.;Zhang,M.X.;Zhu,Y.M.;Zhang,Z.J.*CombinationofTNF-αandGrapheneOxide-LoadedBEZ235toEnhanceApoptosisofPIK3CAMutantColorectalCancerCells,J.Mater.Chem.B,2013,1,5602-5610.16.Huang,J.;Zong,C.;Shen,H.;Liu,X.J.;Ren,B.;*Zhang,Z.J.*IntracellularTrackingofDrugReleasefromGrapheneOxidebySurface-EnhancedRamanSpectroscopy,Nanoscale,2013,5,10591-10598.15.Liu,G.;Shen,H.;Mao,J.N.;Zhang,L.M.;Jiang,Z.;Sun,T.;Lan,Q.;*Zhang,Z.J.*Transferrinmodifiedgrapheneoxideforglioma-targeteddrugdelivery:invitroandinvivoevaluations,ACSAppl.Mater.Interfaces,2013,5,6909-6914.14.Zhang,L.M.;Wang,Z.L.;Lu,Z.X.;Shen,H.;Huang,J.;Zhao,Q.H.;Liu,M.;He,N.Y.;*Zhang,Z.J.*PEGylatedReducedGrapheneOxideasaSuperiorssRNADeliverySystem,J.Mater.Chem.B,2013,1,749-755.13.Shen,H.;Liu,M.;He,H.X.;Zhang,L.M.;Huang,J.;Chong,Y.;Dai,J.W.;Zhang,Z.J.*PEGylatedGrapheneOxide-MediatedProteinDeliveryforCellFunctionRegulation,ACSAppl.Mater.Interfaces,2012,4,6317-6323.12.Chen,W.H.;Cao,Y.H.;Liu,M.;Zhao,Q.H.;Huang,J.;Zhang,H.L.;Deng,Z.W.;Dai,J.W.;Williams,D.F.;Zhang,Z.J.*RotavirusCapsidSurfaceProteinVP4-CoatedFe3O4Nanoparticles:ATheranosticNanoplatformforEfficientCellularImagingandDrugDelivery,Biomaterials,2012,33,7895-7902.11.Huang,J.;Zong,C.;Shen,H.;Liu,M.;Chen,B.;Ren,B.;Zhang,Z.J.*,MechanismofCellularUptakeofGrapheneOxideStudiedbySurface-EnhancedRamanSpectroscopy,Small,2012,8,2577-2584.10.Shen,H.；ZhangL.M.;LiuM.;Zhang,Z.J.*BiomedicalApplicationsofGraphene(Review),Theranostics,2012,3,283-294.9.Liu,M.;Chen,B.;Huang,J.;Zhang,L.M.;Zhang,Z.J.*Polyamidoamine-GraftedMultiwalledCarbonNanotubesforGeneDelivery:Synthesis,TransfectionandIntracellularTrafficking,BioconjugateChem.2011,22,2237-2243.8.Chen,W.H.;Yi,P.W.;Zhang,Y.;Zhang,L.M.;Deng,Z.W.;Zhang,Z.J.*CompositesofAminodextran-CoatedFe3O4NanoparticlesandGrapheneOxideforCellularMagneticResonanceImaging,ACSAppl.Mater.Interfaces,2011,3,4085-4091.7.Chen,B.;Liu,M.;Zhang,L.M.;Huang,J.;Yao,J.L.;*Zhang,Z.J.*Polyethylenimine-FunctionalizedGrapheneOxideasanEfficientGeneDeliveryVector,J.Mater.Chem.2011,21,7736-7741.6.Zhao,Q.H.;Chen,W.H.;Chen,Y.D.;Zhang,L.M.;Zhang,J.P.;Zhang,Z.J.*Self-AssembledVirus-likeParticlesfromRotavirusStructuralProteinVP6forTargetedDrugDelivery,BioconjugateChem.2011,22,346-352.5.Zhang,Y.;Chen,B.;Zhang,L.M.;Huang,J.;Chen,F.H.;Yang,Z.P.;Yao,J.L.;Zhang,Z.J.*ControlledassemblyofFe3O4magneticnanoparticlesongrapheneoxide,Nanoscale,2011,3,1446-1450.4.Zhang,L.M.;Lu,Z.X.;Zhao,Q.H.;Huang,J.;Shen,H.;Zhang,Z.J.*EnhancedchemotherapyefficacybysequentialdeliveryofsiRNAandanticancerdrugsusingPEI–graftedgrapheneoxide,Small,2011,7,460-464.3.Chen,F.H.;Zhang,L.M.;Chen,Q.T.;Zhang,Y.;Zhang,Z.J.*Synthesisofanovelmagneticdrugdeliverysystemcomposedofdoxorubicin-conjugatedFe3O4nanoparticlecoresandaPEG-functionalizedporoussilicashell,Chem.Commun.2010,46,8633-8635.2.Huang,J.;Zhang,L.M.;Chen,B.;Ji,N.;Chen,F.H.;Zhang,Y.;Zhang,Z.J.*Nanocompositesofsize-controlledgoldnanoparticlesandgrapheneoxide:FormationandapplicationsinSERSandcatalysis,Nanoscale,2010,2,2733-2738.1.Zhang,L.M.;Xia,J.G.;Zhao,Q.H.;Liu,L.W.;Zhang,Z.J.*Functionalgrapheneoxideasnanocarriersforcontrolledloadingandtargeteddeliveryofmixedanticancerdrugs,Small,2010,6,537-544.
研究方向 Researchdirection1、纳米载药体系与诊疗一体化纳米平台的构建2、纳米支架材料对干细胞功能的调控3、纳米生物学效应