导师信息#兰州大学生命科学学院导师介绍#何永兴

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学习经历
2011/02-2013/02，加州大学伯克利分校，生物物理系，博士后
2005/09-2010/12，中国科大，生化与分子生物系，博士
2001/09-2005/07，中国科大，生命科学院，学士。
工作经历
2013/03-今，兰州大学引进人才，副教授。
教学及指导研究生情况 主讲本科生必修课《生物信息学》，选修课《生物大分子的结构与功能》。
发表论文及专著
1: Mu Y, Lian FM, Teng YB, Ao J, Jiang YL, He YX, Chen Y, Zhou CZ, Chen X. TheN-terminal β-sheet of peroxiredoxin 4 in the large yellow croaker Pseudosciaenacrocea is involved in its biological functions. PLoS One. 2013;8(2):e57061.
2: He YX, Zhang NN, Li WF, Jia N, Chen BY, Zhou K, Zhang J, Chen Y, Zhou CZ.N-Terminal domain of Bombyx mori fibroin mediates the assembly of silk inresponse to pH decrease. J Mol Biol. 2012 May 4;418(3-4):197-207.
3: Kang Y, He YX, Zhao MX, Li WF. Structures of native and Fe-substituted SOD2from Saccharomyces cerevisiae. Acta Crystallogr Sect F Struct Biol Cryst Commun.2011 Oct 1;67(Pt 10):1173-8.
4: Yang JP, Ma XX, He YX, Li WF, Kang Y, Bao R, Chen Y, Zhou CZ. Crystalstructure of the 30 K protein from the silkworm Bombyx mori reveals a new memberof the β-trefoil superfamily. J Struct Biol. 2011 Jul;175(1):97-103.
5: Du Y, Shi WW, He YX, Yang YH, Zhou CZ, Chen Y. Structures of thesubstrate-binding protein provide insights into the multiple compatible solutebinding specificities of the Bacillus subtilis ABC transporter OpuC. Biochem J.2011 Jun 1;436(2):283-9.
6: Du Y*, He YX*, Zhang ZY, Yang YH, Shi WW, Frolet C, Di Guilmi AM, Vernet T, ZhouCZ, Chen Y. Crystal structure of the mucin-binding domain of Spr1345 fromStreptococcus pneumoniae. J Struct Biol. 2011 Apr;174(1):252-7.7: Ma G, Yu J, Xiao Y, Chan D, Gao B, Hu J, He Y, Guo S, Zhou J, Zhang L, Gao L,Zhang W, Kang Y, Cheah KS, Feng G, Guo X, Wang Y, Zhou CZ, He L. Indian hedgehogmutations causing brachydactyly type A1 impair Hedgehog signal transduction atmultiple levels. Cell Res. 2011 Sep;21(9):1343-57.8: Zhang X, Teng YB, Liu JP, He YX, Zhou K, Chen Y, Zhou CZ. Structural insights into the catalytic mechanism of the yeast pyridoxal 5-phosphate synthase Snz1. Biochem J. 2010 Dec 15;432(3):445-50.
9: Zhao MX, Jiang YL, He YX, Chen YF, Teng YB, Chen Y, Zhang CC, Zhou CZ. Structural basis for the allosteric control of the global transcription factor NtcA by the nitrogen starvation signal 2-oxoglutarate. Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12487-92.
10: Du Y, He YX, Gaowa S, Zhang X, Chen Y, Zhang SC, Zhou CZ. Crystal structures of the apo and GDP-bound forms of a cupin-like protein BbDUF985 from Branchiostoma belcheri tsingtauense. Proteins. 2010 Sep;78(12):2714-9.
11: Luo M, Jiang YL, Ma XX, Tang YJ, He YX, Yu J, Zhang RG, Chen Y, Zhou CZ. Structural and biochemical characterization of yeast monothiol glutaredoxin Grx6. J Mol Biol. 2010 May 14;398(4):614-22.
12: Zhang NN, He YX, Li WF, Teng YB, Yu J, Chen Y, Zhou CZ. Crystal structures of holo and Cu-deficient Cu/Zn-SOD from the silkworm Bombyx mori and the implications in amyotrophic lateral sclerosis. Proteins. 2010 Jun;78(8):1999-2004.
13: He YX, Huang L, Xue Y, Fei X, Teng YB, Rubin-Pitel SB, Zhao H, Zhou CZ. Crystal structure and computational analyses provide insights into the catalytic mechanism of 2,4-diacetylphloroglucinol hydrolase PhlG from Pseudomonas fluorescens. J Biol Chem. 2010 Feb 12;285(7):4603-11.
14: Teng YB, Jiang YL, He YX, He WW, Lian FM, Chen Y, Zhou CZ. Structural insights into the substrate tunnel of Saccharomyces cerevisiae carbonic anhydrase Nce103. BMC Struct Biol. 2009 Oct 24;9:67.
15: Ma XX, Jiang YL, He YX, Bao R, Chen Y, Zhou CZ. Structures of yeast glutathione-S-transferase Gtt2 reveal a new catalytic type of GST family. EMBO Rep. 2009 Dec;10(12):1320-6.
16: Teng YB, Ma XX, He YX, Jiang YL, Du J, Xiang C, Chen Y, Zhou CZ. Crystal structure of Arabidopsis translation initiation factor eIF-5A2. Proteins. 2009 Nov 15;77(3):736-40.
17: Wang Y, He YX, Yu J, Zhou CZ. Cloning, overproduction, purification, crystallization and preliminary X-ray diffraction analysis of yeast glutaredoxin Grx5. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Jun 1;65(Pt 6):651-3.
18: He YX, Gui L, Liu YZ, Du Y, Zhou Y, Li P, Zhou CZ. Crystal structure of Saccharomyces cerevisiae glutamine synthetase Gln1 suggests a nanotube-like supramolecular assembly. Proteins. 2009 Jul;76(1):249-54.
19: Huang L, Sun F, Liang C, He YX, Bao R, Liu L, Zhou CZ. Crystal structure of LZ-8 from the medicinal fungus Ganoderma lucidium. Proteins. 2009 May 1;75(2):524-7. doi: 10.1002/prot.22346.
20: Zhang WJ*, He YX*, Yang Z, Yu J, Chen Y, Zhou CZ. Crystal structure of glutathione-dependent phospholipid peroxidase Hyr1 from the yeast Saccharomyces cerevisiae. Proteins. 2008 Dec;73(4):1058-62.
21: Wang S, He YX, Bao R, Teng YB, Ye BP, Zhou CZ. Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of hypothetical protein SCO4226 from Streptomyces coelicolor A3(2). Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Sep 1;64(Pt 9):847-50.
参与翻译编写《英汉生物技术词典》，化学工业出版社，2009.